Project Vital Sign ® is an effort to address critical issues that are vital to women’s health. Menstruation is a unique indicator of a woman’s overall emotional and physical health. The mission of Project Vital Sign is to identify critical issues linked to the menstrual cycle as well as to address misconceptions about it.  Project Vital Sign is comprised of four main projects: The Menstrual Cycle is a Vital Sign ®, Study of Puberty Across the Nation (SPAN), Primary Ovarian Insufficiency/Premature Ovarian Failure Campaign (POI/POF) and Prescriptions for Coping ®.